Multiscale network dynamics between heart rate and locomotor activity are altered in schizophrenia.

ABSTRACT:

Objective

Changes in heart rate (HR) and locomotor activity reflect changes in autonomic physiology, behavior, and mood. These systems may involve interrelated neural circuits that are altered in psychiatric illness, yet their interactions are poorly understood. We hypothesized interactions between HR and locomotor activity could be used to discriminate patients with schizophrenia from controls, and would be less able to discriminate non-psychiatric patients from controls.

Approach

HR and locomotor activity were recorded via wearable patches in 16 patients with schizophrenia and 19 healthy controls. Measures of signal complexity and interactions were calculated over multiple time scales, including sample entropy, mutual information, and transfer entropy. A support vector mac

SUBMITTER: Reinertsen E 

PROVIDER: S-EPMC6258081 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature