Ontology highlight
ABSTRACT:
SUBMITTER: Fong KW
PROVIDER: S-EPMC6258673 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature communications 20181127 1
TRIM24 is an effector substrate of the E3 ubiquitin ligase adaptor SPOP and becomes stabilized in prostate cancer (PCa) with SPOP mutations. However, how TRIM24 protein is regulated in the vast majority of SPOP-wildtype PCa is unknown. Here we report TRIM28 as a critical upstream regulator of TRIM24. TRIM28 protein interacts with TRIM24 to prevent its ubiquitination and degradation by SPOP. Further, TRIM28 facilitates TRIM24 occupancy on the chromatin and, like TRIM24, augments AR signaling. TRI ...[more]