Ontology highlight
ABSTRACT:
SUBMITTER: Hadi T
PROVIDER: S-EPMC6258757 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature communications 20181127 1
Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix (ECM) fragmentation and inflammation. However, the mechanisms by which these events are coupled thereby fueling focal vascular damage are undefined. Here we report through single-cell RNA-sequencing of diseased aorta that the neuronal guidance cue netrin-1 can act at the interface of macrophage-driven injury and ECM degradation. Netrin-1 expression peaks in human and murine aneurysmal macrophages. Targeted delet ...[more]