Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1.
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ABSTRACT:
SUBMITTER: Staeheli P
PROVIDER: S-EPMC6258936 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1.
Staeheli Peter P Haller Otto O
Journal of virology 20181127 24
Interferons limit viral replication by inducing intracellular restriction factors, such as the GTPase MxB (also designated MX2), which inhibits HIV-1 and, as recently shown, herpesviruses. Inhibition of these viruses occurs at ill-defined steps after viral entry and requires formation of MxB dimers or oligomers, but GTP hydrolysis is needed only for blocking herpesviruses. Together with previous findings on related MxA, the new research on MxB highlights the mechanistic diversity by which MX pro ...[more]
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