Ontology highlight
ABSTRACT:
SUBMITTER: Finnema SJ
PROVIDER: S-EPMC6259313 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Finnema Sjoerd J SJ Nabulsi Nabeel B NB Mercier Joël J Lin Shu-Fei SF Chen Ming-Kai MK Matuskey David D Gallezot Jean-Dominique JD Henry Shannan S Hannestad Jonas J Huang Yiyun Y Carson Richard E RE
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170809 11
Synaptic vesicle glycoprotein 2A (SV2A) is ubiquitously present in presynaptic terminals. Here we report kinetic modeling and test-retest reproducibility assessment of the SV2A positron emission tomography (PET) radioligand [<sup>11</sup>C]UCB-J in humans. Five volunteers were examined twice on the HRRT after bolus injection of [<sup>11</sup>C]UCB-J. Arterial blood samples were collected for measurements of radiometabolites and free fraction. Regional time-activity curves were analyzed with 1-ti ...[more]