Imaging microglial activation and amyloid burden in amnestic mild cognitive impairment.

ABSTRACT: Amnestic mild cognitive impairment (aMCI) is defined as a transitional state between normal aging and Alzheimer's disease (AD). Given the replicated finding of increased microglial activation in AD, we sought to investigate whether microglial activation is also elevated in aMCI and whether it is related to amyloid beta (Aβ) burden in-vivo . Eleven aMCI participants and 14 healthy volunteers completed positron emission tomography (PET) scans with [¹⁸F]-FEPPA and [¹¹C]-PIB. Given the known sensitivity in affinity of second-generation TSPO radioligands, participants were genotyped for the TSPO polymorphism and only high-affinity binders were included. Dynamic [¹⁸F]-FEPPA PET images were analyzed using the 2-tissue compartment model with arterial plasma input f

SUBMITTER: Knezevic D 

PROVIDER: S-EPMC6259323 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature