Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh J
PROVIDER: S-EPMC6260170 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Ghosh Jyotirmoy J Chowdhury Anindya Roy AR Srinivasan Satish S Chattopadhyay Mrittika M Bose Moumita M Bhattacharya Sabyasachi S Raza Haider H Fuchs Serge Y SY Rustgi Anil K AK Gonzalez Frank J FJ Avadhani Narayan G NG
Toxicological sciences : an official journal of the Society of Toxicology 20181201 2
We previously reported that mitochondrial CYP1 enzymes participate in the metabolism of polycyclic aromatic hydrocarbons and other carcinogens leading to mitochondrial dysfunction. In this study, using Cyp1b1-/-, Cyp1a1/1a2-/-, and Cyp1a1/1a2/1b1-/- mice, we observed that cigarette and environmental toxins, namely benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induce pancreatic mitochondrial respiratory dysfunction and pancreatitis. Our results suggest that aryl hydrocarbon ...[more]