Dataset Information

Treatment of candidemia in a nationwide setting: increased survival with primary echinocandin treatment.

ABSTRACT:

Background

In accordance with international guidelines, primary antifungal treatment (AFT) of candidemia with echinocandins has been nationally recommended in Denmark since 2009. Our nationwide cohort study describes the management of candidemia treatment focusing on the impact of prophylactic AFT on species distribution, the rate of adherence to the recommended national guidelines for AFT, and the effect of AFT on patient outcomes.

Materials and methods

Incident candidemia cases from a 2-year period, 2010-2011, were included. Information on AFT was retrospectively collected from patient charts. Vital status was obtained from the Danish Civil Registration System. HRs of mortality were reported with 95% CIs using Cox regression.

Results

A total of 841 candidemia patients was identified. Prior to candidemia diagnosis, 19.3% of patients received AFT (162/841). The risk of non-albicans candidemia increased after prior AFT (59.3% vs 45.5% among nontreated). Echinocandins as primary AFT were given for 44.2% (302/683) of patients. Primary treatment with echinocandins resulted in adequate treatment in a higher proportion of patients (97.7% vs 72.1%) and was associated with lower 0- to 14-day mortality compared with azole treatment (adj. HR 0.76, 95% CI: 0.55-1.06). Significantly lower 0- to 14-day mortality was observed for patients with Candida glabrata and Candida krusei with echinocandin treatment compared with azole treatment (adj. HR 0.50, 95% CI: 0.28-0.89), but not for patients with Candida albicans or Candida tropicalis.

Conclusion

The association shown between prior AFT and non-albicans species underlines the importance of treatment history when selecting treatment for candidemia. Compliance with national recommendations was low, but similar to previously reported international rates. Primary treatment of candidemia with echinocandins compared with azoles yielded both a higher proportion of adequately treated patients and improved mortality rates. This real-life setting supports guidelines recommendation, and further focus on compliance with these seems warranted.

SUBMITTER: Lausch KR

PROVIDER: S-EPMC6260183 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Treatment of candidemia in a nationwide setting: increased survival with primary echinocandin treatment.

Lausch Karen Rokkedal KR Søgaard Mette M Rosenvinge Flemming Schønning FS Johansen Helle Krogh HK Boysen Trine T Røder Bent Løwe BL Mortensen Klaus Leth KL Nielsen Lene L Lemming Lars L Olesen Bente B Leitz Christine C Kristensen Lise L Dzajic Esad E Østergaard Lars Jørgen LJ Schønheyder Henrik Carl HC Arendrup Maiken Cavling MC

Infection and drug resistance 20181123

<h4>Background</h4>In accordance with international guidelines, primary antifungal treatment (AFT) of candidemia with echinocandins has been nationally recommended in Denmark since 2009. Our nationwide cohort study describes the management of candidemia treatment focusing on the impact of prophylactic AFT on species distribution, the rate of adherence to the recommended national guidelines for AFT, and the effect of AFT on patient outcomes.<h4>Materials and methods</h4>Incident candidemia cases ...[more]

PMID: 30538511

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Dataset Information

Treatment of candidemia in a nationwide setting: increased survival with primary echinocandin treatment.

Background

Materials and methods

Results

Conclusion

Publications

Treatment of candidemia in a nationwide setting: increased survival with primary echinocandin treatment.

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