Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study.

ABSTRACT:

Objective

To assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia.

Methods

We evaluated dementia-free Framingham Heart Study (generation 3) participants (mean age 48.5 years, 46.8% men) who underwent cognitive testing for memory, abstract reasoning, visual perception, attention, and executive function (n = 2,231) and brain MRI (n = 2018) to assess total white matter, lobar gray matter, and white matter hyperintensity volumes and fractional anisotropy (FA) measures. We used linear and logistic regression to assess the relations of cortisol (categorized in tertiles, with the middle tertile as referent) to measures of cognition, MRI volumes, presence o

SUBMITTER: Echouffo-Tcheugui JB 

PROVIDER: S-EPMC6260201 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature