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Marital distress, depression, and a leaky gut: Translocation of bacterial endotoxin as a pathway to inflammation.


ABSTRACT: BACKGROUND:Marital distress and depression work in tandem to escalate risks for inflammation-related disorders. Translocation of bacterial endotoxin (lipopolysaccharide, LPS) from the gut microbiota to blood circulation stimulates systemic inflammatory responses. METHODS:To investigate increased gut permeability (a "leaky gut") as one potential mechanistic pathway from marital distress and depression to heightened inflammation, this secondary analysis of a double-blind, randomized crossover study examined serial assessments of two endotoxin biomarkers, LPS-binding protein (LBP) and soluble CD14 (sCD14), as well as C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-?) during two separate 9.5?h visits. The 43 (N?=?86) healthy married couples, ages 24-61 (mean?=?38.22), discussed a marital disagreement during both visits; behavioral coding of these interactions provided data on hostile marital behaviors, a hallmark of marital distress. The Structured Diagnostic Interview for DSM-IV assessed participants' mood disorder history. RESULTS:Participants with more hostile marital interactions had higher LBP than those who were less hostile. Additionally, the combination of more hostile marital interactions with a mood disorder history was associated with higher LBP/sCD14 ratios. Higher LBP and LBP/sCD14 were associated with greater CRP production; for example, only 21% of low LBP participants (lowest quartile) had average CRP across the day > 3, compared to 79% of those in the highest quartile. Higher sCD14 was associated with higher IL-6. CONCLUSIONS:These bacterial LPS translocation data illustrate how a distressed marriage and a mood disorder history can promote a proinflammatory milieu through increased gut permeability, thus fueling inflammation-related disorders.

SUBMITTER: Kiecolt-Glaser JK 

PROVIDER: S-EPMC6260591 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Marital distress, depression, and a leaky gut: Translocation of bacterial endotoxin as a pathway to inflammation.

Kiecolt-Glaser Janice K JK   Wilson Stephanie J SJ   Bailey Michael L ML   Andridge Rebecca R   Peng Juan J   Jaremka Lisa M LM   Fagundes Christopher P CP   Malarkey William B WB   Laskowski Bryon B   Belury Martha A MA  

Psychoneuroendocrinology 20180804


<h4>Background</h4>Marital distress and depression work in tandem to escalate risks for inflammation-related disorders. Translocation of bacterial endotoxin (lipopolysaccharide, LPS) from the gut microbiota to blood circulation stimulates systemic inflammatory responses.<h4>Methods</h4>To investigate increased gut permeability (a "leaky gut") as one potential mechanistic pathway from marital distress and depression to heightened inflammation, this secondary analysis of a double-blind, randomized  ...[more]

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