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Three new oblongolides from Phomopsis sp. XZ-01, an endophytic fungus from Camptotheca acuminate.


ABSTRACT: Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds--oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12)--were isolated from the endophytic fungal strain Phomopsis sp. XZ-01 of Camptotheca acuminate. Their structures were elucidated by spectroscopic analyses, including 1H- and 13C-NMR, 2D NMR (HSQC, HMBC, 1H-1H COSY and NOESY) and HR-FT-MS. Cytotoxic activities of these compounds were evaluated. Some of them showed weak selective activities.

SUBMITTER: Lin T 

PROVIDER: S-EPMC6260605 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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Three new oblongolides from Phomopsis sp. XZ-01, an endophytic fungus from Camptotheca acuminate.

Lin Ting T   Wang Guang Hui GH   Lin Xiang X   Hu Zhi Yu ZY   Chen Quan Cheng QC   Xu Yang Y   Zhang Xiao Kun XK   Chen Hai Feng HF  

Molecules (Basel, Switzerland) 20110419 4


Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds--oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12)--were isolated from the endophytic fungal strain Phomopsis sp. XZ-01 of Camptotheca acuminate. Their structures were elucidated by spectroscopic analyses, including 1H- and 13C-NMR, 2D NMR (HSQC, HMBC, 1H-1H COSY and N  ...[more]

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