Prognostic significance of supradiaphragmatic lymph node metastasis detected by ¹⁸F-FDG PET/CT in advanced epithelial ovarian cancer.

ABSTRACT:

Background

Supradiaphragmatic lymph node metastases (SdLNM) are frequently identified using ¹⁸F-FDG positron emission tomography/computed tomography (PET/CT) in advanced epithelial ovarian cancers (AEOC). This study aimed to determine the prognostic significance of SdLNM detected by PET/CT in patients with AEOC.

Methods

Medical records of patients diagnosed with AEOC were retrospectively registered from January 2009 to July 2015. Patients were categorized according to PET/CT stage: PET/CT stage III, PET/CT stage IV with SdLNM, and PET/CT stage IV with other metastases. Clinicopathologic characteristics, recurrence patterns, survival outcomes were compared according to PET/CT stage. Anatomical distribution of SdLNM and effect of thoracic debulking surgery were estimated.

Results

A total of 295 patients were identified, including 176 patients who underwent primary debulking surgeries (PDS). Progression-free (P?=?0.671) and overall (P?=?0.525) survival did not differ significantly between patients with PET/CT IV with SdLNM and PET/CT IV with other metastases; however, patients with PET/CT IV with SdLNM had significantly poorer progression-free (P?ConclusionsSdLNM detected using preoperative PET/CT are a negative prognostic factor in AEOC. Resection of suspicious SdLNM may not have effect to survival of patients with AEOC.

SUBMITTER: Lee IO 

PROVIDER: S-EPMC6260780 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature