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The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC in Cancer.

ABSTRACT: MYC is one of the most important oncogenes in cancer. Indeed, MYC is upregulated in 50-60% of all tumors. MYC overexpression can be achieved through a variety of mechanisms, including gene duplications, chromosomal translocations, or somatic mutations leading to increased MYC stability. However, recent studies have identified numerous tissue-specific noncoding enhancers of MYC that play major roles in cancer, highlighting long-range transcriptional regulation of MYC as a critical novel mechanism leading to MYC hyperactivation and as a potential target for new therapeutic strategies in the near future. Here we summarize the regions and mechanisms involved in the long-range transcriptional regulation of MYC, underscoring the relevance of MYC enhancers both in normal physiological development and in MYC-driven cancer initiation and progression.

SUBMITTER: Lancho O

PROVIDER: S-EPMC6260942 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC in Cancer.

Lancho Olga O Herranz Daniel D

Trends in cancer 20181102 12

MYC is one of the most important oncogenes in cancer. Indeed, MYC is upregulated in 50-60% of all tumors. MYC overexpression can be achieved through a variety of mechanisms, including gene duplications, chromosomal translocations, or somatic mutations leading to increased MYC stability. However, recent studies have identified numerous tissue-specific noncoding enhancers of MYC that play major roles in cancer, highlighting long-range transcriptional regulation of MYC as a critical novel mechanism ...[more]

PMID: 30470303

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