Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Galeno JE
PROVIDER: S-EPMC6261437 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Gómez-Galeno Jorge E JE Hurtado Cecilia C Cheng Jiongjia J Yardimci Ceren C Mercola Mark M Cashman John R JR
Bioorganic & medicinal chemistry letters 20180905 20
The Notch signaling pathway is involved in cell proliferation and differentiation, and has been recognized as an active pathway in regenerating tissue and cancerous cells. Notch signaling inhibition is considered a viable approach to the treatment of a variety of conditions including colorectal cancer, pancreatic cancer, breast cancer and metastatic melanoma. The discovery that the b-annulated dihydropyridine FLI-06 (1) is an inhibitor of the Notch pathway with an EC50 ≈ 2.5 μM prompted us to sc ...[more]