Ontology highlight
ABSTRACT:
SUBMITTER: Jung YS
PROVIDER: S-EPMC6261439 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Jung Youn-Sang YS Wang Wenqi W Jun Sohee S Zhang Jie J Srivastava Mrinal M Kim Moon Jong MJ Lien Esther M EM Shang Joan J Chen Junjie J McCrea Pierre D PD Zhang Songlin S Park Jae-Il JI
Nature cell biology 20181022 11
Epithelial integrity is maintained by the cytoskeleton and through cell adhesion. However, it is not yet known how a deregulated cytoskeleton is associated with cancer. We identified cancer-related regulator of actin dynamics (CRAD) as frequently mutated or transcriptionally downregulated in colorectal cancer. We found that CRAD stabilizes the cadherin-catenin-actin complex via capping protein inhibition. The loss of CRAD inhibits F-actin polymerization and subsequently disrupts the cadherin-cat ...[more]