Ontology highlight
ABSTRACT:
SUBMITTER: Deng Y
PROVIDER: S-EPMC6261503 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Developmental cell 20181101 4
How the principal functions of the Golgi apparatus-protein processing, lipid synthesis, and sorting of macromolecules-are integrated to constitute cargo-specific trafficking pathways originating from the trans-Golgi network (TGN) is unknown. Here, we show that the activity of the Golgi localized SPCA1 calcium pump couples sorting and export of secreted proteins to synthesis of new lipid in the TGN membrane. A secreted Ca<sup>2+</sup>-binding protein, Cab45, constitutes the core component of a Ca ...[more]