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HIV Infection, Pulmonary Tuberculosis, and COPD in Rural Uganda: A Cross-Sectional Study.


ABSTRACT: PURPOSE:HIV is associated with chronic obstructive pulmonary disease (COPD) in high resource settings. Similar relationships are less understood in low resource settings. We aimed to estimate the association between HIV infection, tuberculosis, and COPD in rural Uganda. METHODS:The Uganda Non-communicable Diseases and Aging Cohort study observes people 40 years and older living with HIV (PLWH) on antiretroviral therapy, and population-based HIV-uninfected controls in rural Uganda. Participants completed respiratory questionnaires and post-bronchodilator spirometry. RESULTS:Among 269 participants with spirometry, median age was 52 (IQR 48-55), 48% (n?=?130) were ever-smokers, and few (3%, n?=?9) reported a history of COPD or asthma. All participants with prior tuberculosis (7%, n?=?18) were PLWH. Among 143 (53%) PLWH, median CD4 count was 477?cells/mm3 and 131 (92%) were virologically suppressed. FEV1 was lower among older individuals (-?0.5%pred/year, 95% CI 0.2-0.8, p?

SUBMITTER: North CM 

PROVIDER: S-EPMC6261662 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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HIV Infection, Pulmonary Tuberculosis, and COPD in Rural Uganda: A Cross-Sectional Study.

North Crystal M CM   Allen Joseph G JG   Okello Samson S   Sentongo Ruth R   Kakuhikire Bernard B   Ryan Edward T ET   Tsai Alexander C AC   Christiani David C DC   Siedner Mark J MJ  

Lung 20171219 1


<h4>Purpose</h4>HIV is associated with chronic obstructive pulmonary disease (COPD) in high resource settings. Similar relationships are less understood in low resource settings. We aimed to estimate the association between HIV infection, tuberculosis, and COPD in rural Uganda.<h4>Methods</h4>The Uganda Non-communicable Diseases and Aging Cohort study observes people 40 years and older living with HIV (PLWH) on antiretroviral therapy, and population-based HIV-uninfected controls in rural Uganda.  ...[more]

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