Ontology highlight
ABSTRACT:
SUBMITTER: Barben M
PROVIDER: S-EPMC6261999 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Barben Maya M Ail Divya D Storti Federica F Klee Katrin K Schori Christian C Samardzija Marijana M Michalakis Stylianos S Biel Martin M Meneau Isabelle I Blaser Frank F Barthelmes Daniel D Grimm Christian C
Cell death and differentiation 20180417 12
Reduced choroidal blood flow and tissue changes in the ageing human eye impair oxygen delivery to photoreceptors and the retinal pigment epithelium. As a consequence, mild but chronic hypoxia may develop and disturb cell metabolism, function and ultimately survival, potentially contributing to retinal pathologies such as age-related macular degeneration (AMD). Here, we show that several hypoxia-inducible genes were expressed at higher levels in the aged human retina suggesting increased activity ...[more]