Ontology highlight
ABSTRACT:
SUBMITTER: Zhu N
PROVIDER: S-EPMC6262012 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Zhu Ningyu N Wang Xia X Li Dongsheng D Lin Yuan Y You Xuefu X Jiang Jiandong J Xu Yanni Y Jiang Wei W Si Shuyi S
Scientific reports 20181128 1
The anti-tuberculosis (TB) agent IMB-T130 was speculated to be a multi-target compound. In this research, we found that IMB-T130 inhibits the catalytic activity of Mycobacterium tuberculosis 3-dehydroquinate synthase (MtDHQS), the enzyme in the second step of the shikimate pathway. IMB-T130 was identified as a selective inhibitor of MtDHQS with an IC<sub>50</sub> value of 0.87 μg/mL. The interaction between the compound and protein was analysed by surface plasmon resonance and circular dichroism ...[more]