Ontology highlight
ABSTRACT:
SUBMITTER: Lu WJ
PROVIDER: S-EPMC6262437 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Lu Wan Jung WJ Chung Chi Li CL Chen Ray Jade RJ Huang Li Ting LT Lien Li Ming LM Chang Chao Chien CC Lin Kuan Hung KH Sheu Joen Rong JR
Journal of clinical medicine 20181114 11
Phospholipase D (PLD) is involved in many biological processes. PLD1 plays a crucial role in regulating the platelet activity of mice; however, the role of PLD in the platelet activation of humans remains unclear. Therefore, we investigated whether PLD is involved in the platelet activation of humans. Our data revealed that inhibition of PLD1 or PLD2 using pharmacological inhibitors effectively inhibits platelet aggregation in humans. However, previous studies have showed that PLD1 or PLD2 delet ...[more]