Cross-Sectional and Longitudinal Assessment of Retinal Sensitivity in Patients With Childhood-Onset Stargardt Disease.

ABSTRACT:

Purpose

We assess cross-sectional and longitudinal microperimetry and full-field static perimetry-derived retinal sensitivity with conventional and volumetric indices of retinal function in childhood-onset Stargardt disease (STGD1).

Methods

Subjects with molecularly confirmed childhood-onset STGD1 underwent full-field static perimetry and/or microperimetry using custom designed grids. Mean sensitivity (MS) and total volume (V_TOT) were computed for each microperimetry test. MS, V_TOT, and central field volume (V₃₀) were computed for each full-field static perimetry test. Subjects under 18 years old at baseline were classified as children and subjects 18 years or older as adults.

Results

A total of 43 children (mean age at baseline, 13.0

SUBMITTER: Tanna P 

PROVIDER: S-EPMC6262645 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature