Ontology highlight
ABSTRACT:
SUBMITTER: Sanford AG
PROVIDER: S-EPMC6262783 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Sanford A G AG Schulze T T TT Potluri L P LP Watson G F GF Darner E B EB Zach S J SJ Hemsley R M RM Wallick A I AI Warner R C RC Charman S A SA Wang X X Vennerstrom J L JL Davis P H PH
International journal for parasitology. Drugs and drug resistance 20181110 3
Toxoplasma gondii is an obligate intracellular parasite with global incidence. The acute infection, toxoplasmosis, is treatable but current regimens have poor host tolerance and no cure has been found for latent infections. This work builds upon a previous high throughput screen which identified benzoquinone acyl hydrazone (KG8) as the most promising compound; KG8 displayed potent in vitro activity against T. gondii but only marginal in vivo efficacy in a T. gondii animal model. To define the po ...[more]