Ontology highlight
ABSTRACT:
SUBMITTER: Moschitto MJ
PROVIDER: S-EPMC6262895 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Organic letters 20180716 15
( S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid (OV329, 1) is being developed for the treatment of epilepsy and addiction. The previous 14-step synthesis of OV329 was low yielding, involved an unselective α-elimination to form the cyclopentene, required the use of tert-butyllithium, and produced toxic selenium byproducts in the penultimate step. A new synthesis, which avoids the aforementioned issues, was carried out on large scale, reducing the step count from 14 to 9 steps ...[more]