Ontology highlight
ABSTRACT:
SUBMITTER: Midde K
PROVIDER: S-EPMC6263091 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Midde Krishna K Sun Nina N Rohena Cristina C Joosen Linda L Dhillon Harsharan H Ghosh Pradipta P
iScience 20181115
Molecular imaging of metastatic "potential" is an unvanquished challenge. To engineer biosensors that can detect and measure the metastatic "potential" of single living cancer cells, we carried out a comprehensive analysis of the pan-cancer phosphoproteome to search for actin remodelers required for cell migration, which are enriched in cancers but excluded in normal cells. Only one phosphoprotein emerged, tyr-phosphorylated CCDC88A (GIV/Girdin), a bona fide metastasis-related protein across a v ...[more]