Ontology highlight
ABSTRACT:
SUBMITTER: Di Menna L
PROVIDER: S-EPMC6263139 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Neuropharmacology 20171025
mGlu5 receptors are involved in mechanisms of activity-dependent synaptic plasticity, and are targeted by drugs developed for the treatment of CNS disorders. We report that mGlu3 receptors, which are traditionally linked to the control of neurotransmitter release, support mGlu5 receptor signaling in neurons and largely contribute to the robust mGlu5 receptor-mediated polyphosphoinositide hydrolysis in the early postnatal life. In cortical pyramidal neurons, mGlu3 receptor activation potentiated ...[more]