Ontology highlight
ABSTRACT:
SUBMITTER: Elison GL
PROVIDER: S-EPMC6263159 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Elison Gregory L GL Xue Yuan Y Song Ruijie R Acar Murat M
Cell reports 20181001 3
Despite advances made in understanding the effects of promoter structure on transcriptional activity, limited knowledge exists regarding the role played by chromatin architecture in transcription. Previous work hypothesized that transcription from the bidirectional GAL1/GAL10 promoter is controlled through looping of its UAS region around a nonstandard nucleosome. Here, by editing the GAL1/GAL10 promoter at high resolution, we provide insights into bidirectional expression control. We demonstrat ...[more]