Ontology highlight
ABSTRACT:
SUBMITTER: Clements JD
PROVIDER: S-EPMC6263661 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Clements John David JD Perez Ruixo Juan Jose JJ Gibbs John P JP Doshi Sameer S Perez Ruixo Carlos C Melhem Murad M
CPT: pharmacometrics & systems pharmacology 20181015 11
Optimal dose selection in clinical trials is problematic when efficacious and toxic concentrations are close. A novel quantitative approach follows for optimizing dose titration in clinical trials. A system of pharmacokinetics (PK), pharmacodynamics, efficacy, and toxicity was simulated for scenarios characterized by varying degrees of different types of variability. Receiver operating characteristic (ROC) and clinical trial simulation (CTS) were used to optimize drug titration by maximizing eff ...[more]