Dataset Information

Optical Fibre-Based Pulse Oximetry Sensor with Contact Force Detection.

ABSTRACT: A novel optical sensor probe combining monitoring of blood oxygen saturation (SpO₂) with contact pressure is presented. This is beneficial as contact pressure is known to affect SpO₂ measurement. The sensor consists of three plastic optical fibres (POF) used to deliver and collect light for pulse oximetry, and a fibre Bragg grating (FBG) sensor to measure contact pressure. All optical fibres are housed in a biocompatible epoxy patch which serves two purposes: (i) to reduce motion artefacts in the photoplethysmogram (PPG), and (ii) to transduce transverse loading into an axial strain in the FBG. Test results show that using a combination of pressure measuring FBG with a reference FBG, reliable results are possible with low hysteresis which are relatively immune to the effects of temperature. The sensor is used to measure the SpO₂ of ten volunteers under different contact pressures with perfusion and skewness indices applied to assess the quality of the PPG. The study revealed that the contact force ranging from 5 to 15 kPa provides errors of <2%. The combined probe has the potential to improve the reliability of reflectance oximeters. In particular, in wearable technology, the probe should find use in optimising the fitting of garments incorporating this technology.

SUBMITTER: Liu C

PROVIDER: S-EPMC6263952 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Optical Fibre-Based Pulse Oximetry Sensor with Contact Force Detection.

Liu Chong C Liu Chong C Correia Ricardo R Ballaji Hattan Khaled HK Korposh Serhiy S Hayes-Gill Barrie R BR Morgan Stephen P SP

Sensors (Basel, Switzerland) 20181026 11

A novel optical sensor probe combining monitoring of blood oxygen saturation (S<sub>p</sub>O₂) with contact pressure is presented. This is beneficial as contact pressure is known to affect S<sub>p</sub>O₂ measurement. The sensor consists of three plastic optical fibres (POF) used to deliver and collect light for pulse oximetry, and a fibre Bragg grating (FBG) sensor to measure contact pressure. All optical fibres are housed in a biocompatible epoxy patch which serves two purposes: (i) to reduce ...[more]

PMID: 30373119

Similar Datasets

Project description:BackgroundPulse oximetry has not been thoroughly evaluated for assessment of oxygenation in conscious foals. Compared with invasive arterial blood sampling, it is a painless and non-invasive method for real-time monitoring of blood oxygen saturation. The aim of this prospective clinical study was to evaluate the usability, validity, and reliability of pulse oximetry at two measuring sites (lip and caudal abdominal skin fold) for blood oxygen saturation measurement in conscious foals with and without respiratory compromise. Thirty-two foals under one month of age were used. Nineteen foals had normal respiratory and cardiovascular function, and 13 had pneumonia. Pulse oximetry with a transmittance sensor was performed in triplicate on each foal's lip (n = 196 measurements) and/or skin fold (n = 338 measurements), and arterial blood sample was collected. The oxygen saturation values measured by pulse oximetry from the lip and skin fold were compared with each other (n = 58 measurement pairs) and with the calculated arterial oxygen saturation based on arterial blood samples (n = 93 measurement pairs). Furthermore, repeatability of the pulse oximetry measurements was assessed.ResultsMeasured blood oxygen saturation was clearly associated with the calculated saturation, but on average (± SD) it was 1.8 (± 3.3) percentage units higher from the lip and 5.7 (± 4.3) percentage units higher from the skin fold than the calculated saturation. In concurrent lip and skin fold measurements within a foal, the skin fold measurements were 2.4 (± 2.4) percentage units higher than the lip measurements. The repeatability of three pulse oximetry saturation measurement results was moderate to good and significantly improved when the measurement furthest from the middle-measured value was excluded. The most deviating measurement was often obtained first. Pulse oximetry in general was well tolerated and easy to perform, but as expected in conscious foals, movement and contact problems generated occasional technical difficulties in some individuals.ConclusionsIn conscious foals, pulse oximetry with a transmittance sensor attached to the lip (but not to the skin fold) is a clinically applicable and valid method for arterial blood oxygen saturation determination. Several measurements should be obtained and outliers discarded to obtain a reliable result.

Project description:Dysregulated production of hydrogen sulphide in the human body has been associated with various diseases including cancer, underlining the importance of accurate detection of this molecule. Here, we report the detection of hydrogen sulphide using fluorescence-emission enhancement of two 1,8-naphthalimide fluorescent probes with an azide moiety in position 4. One probe, serving as a control, featured a methoxyethyl moiety through the imide to evaluate its effectiveness for hydrogen sulphide detection, while the other probe was modified with (3-aminopropyl)triethoxysilane (APTES) to enable direct covalent attachment to an optical fibre tip. We coated the optical fibre tip relatively homogeneously with the APTES-azide fluorophore, as confirmed via x-ray photoelectron spectroscopy (XPS). The absorption and fluorescence responses of the control fluorophore free in PBS were analysed using UV-Vis and fluorescence spectrophotometry, while the fluorescence emission of the APTES-azide fluorophore-coated optical fibres was examined using a simple, low-cost optical fibre-based setup. Both fluorescent probes exhibited a significant increase (more than double the initial value) in fluorescence emission upon the addition of HS- when excited with 405 nm. However, the fluorescence enhancement of the coated optical fibres demonstrated a much faster response time of 2 min (time for the fluorescence intensity to reach 90% of its maximum value) compared to the control fluorophore in solution (30 min). Additionally, the temporal evolution of fluorescence intensity of the fluorophore coated on the optical fibre was studied at two pH values (7.4 and 6.4), demonstrating a reasonable overlap and confirming the compound pH insensitivity within this range. The promising results from this study indicate the potential for developing an optical fibre-based sensing system for HS- detection using the synthesised fluorophore, which could have significant applications in health monitoring and disease detection.

Dataset Information

Optical Fibre-Based Pulse Oximetry Sensor with Contact Force Detection.

Publications

Optical Fibre-Based Pulse Oximetry Sensor with Contact Force Detection.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets