Ontology highlight
ABSTRACT:
SUBMITTER: Keller A
PROVIDER: S-EPMC6264140 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Keller Annika A Nuvolone Mario M Abakumova Irina I Chincisan Andra A Reimann Regina R Avar Merve M Heinzer Daniel D Hornemann Simone S Wagner Josephin J Kirschenbaum Daniel D Voigt Fabian F FF Zhu Caihong C Regli Luca L Helmchen Fritjof F Aguzzi Adriano A
PLoS pathogens 20181129 11
Transmissible spongiform encephalopathies (TSEs) are caused by the prion, which consists essentially of PrPSc, an aggregated, conformationally modified form of the cellular prion protein (PrPC). Although TSEs can be experimentally transmitted by intracerebral inoculation, most instances of infection in the field occur through extracerebral routes. The epidemics of kuru and variant Creutzfeldt-Jakob disease were caused by dietary exposure to prions, and parenteral administration of prion-contamin ...[more]