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One-pot synthesis of novel 2,3-dihydro-1H-indazoles.

ABSTRACT: A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%-72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring.

SUBMITTER: Breton GW

PROVIDER: S-EPMC6264256 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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One-pot synthesis of novel 2,3-dihydro-1H-indazoles.

Breton Gary W GW Lepore Antonio J AJ

Molecules (Basel, Switzerland) 20111116 11

A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%-72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring. ...[more]

PMID: 22089862

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