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Diversity oriented design of various benzophenone derivatives and their in vitro antifungal and antibacterial activities.


ABSTRACT: A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacterial activities towards the five vibrios isolated from marine sources. The preliminary structure activity relationship (SAR) of the compounds was also discussed.

SUBMITTER: Sun L 

PROVIDER: S-EPMC6264486 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Diversity oriented design of various benzophenone derivatives and their in vitro antifungal and antibacterial activities.

Sun Li L   Wu Jie J   Luo Min M   Wang Xiaoli X   Pan Man M   Gou Zhaopin Z   Sun Dequn D  

Molecules (Basel, Switzerland) 20111123 11


A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacterial activities towards the five vibrios isolated from marine sources. The preliminary structure activity relationship (SAR) of the compounds was also discussed. ...[more]

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