Ontology highlight
ABSTRACT:
SUBMITTER: Murtha MJ
PROVIDER: S-EPMC6264632 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Murtha Matthew J MJ Eichler Tad T Bender Kristin K Metheny Jackie J Li Birong B Schwaderer Andrew L AL Mosquera Claudia C James Cindy C Schwartz Laura L Becknell Brian B Spencer John David JD
The Journal of clinical investigation 20181112 12
People with diabetes mellitus have increased infection risk. With diabetes, urinary tract infection (UTI) is more common and has worse outcomes. Here, we investigate how diabetes and insulin resistance impact the kidney's innate defenses and urine sterility. We report that type 2 diabetic mice have increased UTI risk. Moreover, insulin-resistant prediabetic mice have increased UTI susceptibility, independent of hyperglycemia or glucosuria. To identify how insulin resistance affects renal antimic ...[more]