Ontology highlight
ABSTRACT:
SUBMITTER: Wei Q
PROVIDER: S-EPMC6264638 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Wei Qingqing Q Sun Haipeng H Song Shuwei S Liu Yong Y Liu Pengyuan P Livingston Man Jiang MJ Wang Jianwen J Liang Mingyu M Mi Qing-Sheng QS Huo Yuqing Y Nahman Norris Stanley NS Mei Changlin C Dong Zheng Z
The Journal of clinical investigation 20181112 12
The pathogenesis of ischemic diseases remains unclear. Here we demonstrate the induction of microRNA-668 (miR-668) in ischemic acute kidney injury (AKI) in human patients, mice, and renal tubular cells. The induction was HIF-1 dependent, as HIF-1 deficiency in cells and kidney proximal tubules attenuated miR-668 expression. We further identified a functional HIF-1 binding site in the miR-668 gene promoter. Anti-miR-668 increased apoptosis in renal tubular cells and enhanced ischemic AKI in mice, ...[more]