Ontology highlight
ABSTRACT:
SUBMITTER: Huber V
PROVIDER: S-EPMC6264733 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20181105 12
The accrual of myeloid-derived suppressor cells (MDSCs) represents a major obstacle to effective immunotherapy in cancer patients, but the mechanisms underlying this process in the human setting remain elusive. Here, we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and resistance to treatment with immune checkpoint inhibitors in melanoma patients. The miRs were identified by transcriptional analyses as being ...[more]