Ontology highlight
ABSTRACT:
SUBMITTER: Webber JT
PROVIDER: S-EPMC6265063 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Webber James T JT Kaushik Swati S Bandyopadhyay Sourav S
Cell systems 20181107 5
Leveraging insights from genomic studies of patient tumors is limited by the discordance between these tumors and the cell line models used for functional studies. We integrate omics datasets using functional networks to identify gene modules reflecting variation between tumors and show that the structure of these modules can be evaluated in cell lines to discover clinically relevant biomarkers of therapeutic responses. Applied to breast cancer, we identify 219 gene modules that capture recurren ...[more]