Ontology highlight
ABSTRACT:
SUBMITTER: van Welsem T
PROVIDER: S-EPMC6265471 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
van Welsem Tibor T Korthout Tessy T Ekkebus Reggy R Morais Dominique D Molenaar Thom M TM van Harten Kirsten K Poramba-Liyanage Deepani W DW Sun Su Ming SM Lenstra Tineke L TL Srivas Rohith R Ideker Trey T Holstege Frank C P FCP van Attikum Haico H El Oualid Farid F Ovaa Huib H Stulemeijer Iris J E IJE Vlaming Hanneke H van Leeuwen Fred F
Nucleic acids research 20181101 21
The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects gene expression and the response to DNA damage, and is enhanced by monoubiquitination of the C-terminus of histone H2B (H2Bub1). To gain more insight into the functions of Dot1, we generated genetic interaction maps of increased-dosage alleles of DOT1. We identified a functional relationship between increased Dot1 dosa ...[more]