Ontology highlight
ABSTRACT:
SUBMITTER: Huang IY
PROVIDER: S-EPMC6266063 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Marine drugs 20181025 11
Memory retrieval dysfunction is a symptom of schizophrenia, autism spectrum disorder (ASD), and absence epilepsy (AE), as well as an early sign of Alzheimer's disease. To date, few drugs have been reported to enhance memory retrieval. Here, we found that a coral-derived natural product, excavatolide-B (Exc-B), enhances contextual memory retrieval in both wild-type and <i>Ca<sub>v</sub>3.2<sup>-/-</sup></i> mice via repressing the delayed rectifier potassium current, thus lowering the threshold f ...[more]