Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer's Disease.

ABSTRACT: The bidirectional communication between the central nervous system (CNS) and the gut microbiota plays a pivotal role in human health. Increasing numbers of studies suggest that the gut microbiota can influence the brain and behavior of patients. Various metabolites secreted by the gut microbiota can affect the cognitive ability of patients diagnosed with neurodegenerative diseases. Nearly one in every ten Korean senior citizens suffers from Alzheimer's disease (AD), the most common form of dementia. This review highlights the impact of metabolites from the gut microbiota on communication pathways between the brain and gut, as well as the neuroinflammatory roles they may have in AD patients. The objectives of this review are as follows: (1) to examine the role of the intestinal microbiota i

SUBMITTER: Giau VV 

PROVIDER: S-EPMC6266223 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature