Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Davis S
PROVIDER: S-EPMC6266398 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
García-Davis Sara S Sifaoui Ines I Reyes-Batlle María M Viveros-Valdez Ezequiel E Piñero José E JE Lorenzo-Morales Jacob J Fernández José J JJ Díaz-Marrero Ana R AR
Marine drugs 20181111 11
Focused on our interest to develop novel antiparasistic agents, the present study was aimed to evaluate the biological activity of an extract of <i>Laurencia johnstonii</i> collected in Baja California Sur, Mexico, against an <i>Acantamoeba castellanii</i> Neff strain. Bioassay-guided fractionation allowed us to identify the amoebicidal diastereoisomers α-bromocuparane (<b>4</b>) and α-isobromocuparane (<b>5</b>). Furthermore, bromination of the inactive laurinterol (<b>1</b>) and isolaurinterol ...[more]