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Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii.

ABSTRACT: Focused on our interest to develop novel antiparasistic agents, the present study was aimed to evaluate the biological activity of an extract of Laurencia johnstonii collected in Baja California Sur, Mexico, against an Acantamoeba castellanii Neff strain. Bioassay-guided fractionation allowed us to identify the amoebicidal diastereoisomers ?-bromocuparane (4) and ?-isobromocuparane (5). Furthermore, bromination of the inactive laurinterol (1) and isolaurinterol (2) yielded four halogenated derivatives, (6)?(9), which improved the activity of the natural sesquiterpenes. Among them, the most active compound was 3?-bromojohnstane (7), a sesquiterpene derivative which possesses a novel carbon skeleton johnstane.

SUBMITTER: Garcia-Davis S

PROVIDER: S-EPMC6266398 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii.

García-Davis Sara S Sifaoui Ines I Reyes-Batlle María M Viveros-Valdez Ezequiel E Piñero José E JE Lorenzo-Morales Jacob J Fernández José J JJ Díaz-Marrero Ana R AR

Marine drugs 20181111 11

Focused on our interest to develop novel antiparasistic agents, the present study was aimed to evaluate the biological activity of an extract of Laurencia johnstonii collected in Baja California Sur, Mexico, against an Acantamoeba castellanii Neff strain. Bioassay-guided fractionation allowed us to identify the amoebicidal diastereoisomers α-bromocuparane (4) and α-isobromocuparane (5). Furthermore, bromination of the inactive laurinterol (1) and isolaurinterol ...[more]

PMID: 30423882

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