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Components from the Leaves and Twigs of Mangrove Lumnitzera racemosa with Anti-Angiogenic and Anti-Inflammatory Effects.

ABSTRACT: One new neolignan, racelactone A (1), together with seven known compounds (2-8) were isolated from the methanolic extract of the leaves and twigs of Lumnitzera racemosa. The structure of racelactone A (1) was determined on the basis of the mass and NMR spectroscopic data interpretation. With respect to bioactivity, compound 1 displayed an anti-angiogenic effect by suppressing tube formation. Furthermore, compounds 1, 4, and 5 showed significant anti-inflammatory effects with IC₅₀ values of 4.95 ± 0.89, 1.95 ± 0.40, and 2.57 ± 0.23 ?M, respectively. The plausible biosynthesis pathway of racelactone A (1) was proposed.

SUBMITTER: Yu SY

PROVIDER: S-EPMC6267291 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Components from the Leaves and Twigs of Mangrove Lumnitzera racemosa with Anti-Angiogenic and Anti-Inflammatory Effects.

Yu Szu-Yin SY Wang Shih-Wei SW Hwang Tsong-Long TL Wei Bai-Luh BL Su Chien-Jung CJ Chang Fang-Rong FR Cheng Yuan-Bin YB

Marine drugs 20181025 11

One new neolignan, racelactone A (1), together with seven known compounds (2-8) were isolated from the methanolic extract of the leaves and twigs of Lumnitzera racemosa. The structure of racelactone A (1) was determined on the basis of the mass and NMR spectroscopic data interpretation. With respect to bioactivity, compound 1 displayed an anti-angiogenic effect by suppressing tube formation. Furthermore, compounds 1, 4, and 5 showed signifi ...[more]

PMID: 30366373

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