Chemiplasmonics for high-throughput biosensors.

ABSTRACT:

Background

The sensitivity of ELISA for biomarker detection can be significantly increased by integrating fluorescence with plasmonics. In surface-plasmon-coupled emission, the fluorophore emission is generally enhanced through the so-called physical mechanism due to an increase in the local electric field. Despite its fairly high enhancement factors, the use of surface-plasmon-coupled emission for high-throughput and point-of-care applications is still hampered due to the need for expensive focusing optics and spectrometers.

Methods

Here, we describe a new chemiplasmonic-sensing paradigm for enhanced emission through the molecular interactions between aromatic dyes and C₆₀ films on Ag substrates.

Results

A 20-fold enhancement in the emission from rhodamine

SUBMITTER: Raghavendra AJ 

PROVIDER: S-EPMC6267718 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature