Ontology highlight
ABSTRACT:
SUBMITTER: Jung JC
PROVIDER: S-EPMC6268178 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Jung Jae-Chul JC Lim Eunyoung E Lee Yongnam Y Min Dongguk D Ricci Jeremy J Park Oe-Sook OS Jung Mankil M
Molecules (Basel, Switzerland) 20120221 2
The total synthesis and structure determination of cis- and trans-flocoumafen was described. The key synthetic steps involve Knoevenagel condensation with p-methoxybenzaldehyde, in situ decarboxylation and intramolecular ring cyclization to construct the tetralone skeleton. Stereospecific reduction of the O-alkylated ketone 13 afforded good yield of precusor alcohol 5. Final coupling of alcohol 5 with 4-hydroxy-coumarin yielded flocoumafen (1). Separation and structure determination of cis- and ...[more]