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Systematic study of the physicochemical properties of a homologous series of aminobisphosphonates.

ABSTRACT: Aminobisphosphonates, e.g., alendronate and neridronate, are a well known class of molecules used as drugs for various bone diseases. Although these molecules have been available for decades, a detailed understanding of their most important physicochemical properties under comparable conditions is lacking. In this study, ten aminobisphosphonates, H(2)N(CH2)(n)C(OH)[P(O)(OH)(2)](2) in which n = 2-5, 7-11 and 15 have been synthesized. Their aqueous solubility as a function of temperature and pH, pK(a-) values, thermal stability, IR absorptions, and NMR spectral data for both liquid (1)H, (13)C, (31)P-NMR and solid state(13)C, (15)N and (31)P-CPMAS NMR) were determined.

SUBMITTER: Saari AL

PROVIDER: S-EPMC6268373 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Systematic study of the physicochemical properties of a homologous series of aminobisphosphonates.

Saari Aino-Liisa AL Hyvönen Helena H Lahtinen Manu M Ylisirniö Markku M Turhanen Petri P Kolehmainen Erkki E Peräniemi Sirpa S Vepsäläinen Jouko J

Molecules (Basel, Switzerland) 20120912 9

Aminobisphosphonates, e.g., alendronate and neridronate, are a well known class of molecules used as drugs for various bone diseases. Although these molecules have been available for decades, a detailed understanding of their most important physicochemical properties under comparable conditions is lacking. In this study, ten aminobisphosphonates, H(2)N(CH2)(n)C(OH)[P(O)(OH)(2)](2) in which n = 2-5, 7-11 and 15 have been synthesized. Their aqueous solubility as a function of temperature and pH, p ...[more]

PMID: 22971579

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Systematic study of the physicochemical properties of a homologous series of aminobisphosphonates.

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Systematic study of the physicochemical properties of a homologous series of aminobisphosphonates.

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