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New bioactive alkyl sulfates from Mediterranean tunicates.

ABSTRACT: Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1-5) including three new molecules 1-3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1-3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells.

SUBMITTER: Imperatore C

PROVIDER: S-EPMC6268736 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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New bioactive alkyl sulfates from Mediterranean tunicates.

Imperatore Concetta C Aiello Anna A D'Aniello Filomena F Luciano Paolo P Vitalone Rocco R Meli Rosaria R Raso Giuseppina Mattace GM Menna Marialuisa M

Molecules (Basel, Switzerland) 20121026 11

Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1-5) including three new molecules 1-3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1-3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophag ...[more]

PMID: 23103530

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