Antiviral effect of matrine against human enterovirus 71.
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ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC6268984 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Antiviral effect of matrine against human enterovirus 71.
Yang Yajun Y Xiu Jinghui J Zhang Xu X Zhang Liangfeng L Yan Kai K Qin Chuan C Liu Jiangning J
Molecules (Basel, Switzerland) 20120829 9
Human enterovirus 71, a member of the Picornaviridae family, is one of the major causative agent of hand, foot and mouth disease in children less than six years old. This illness has caused mortalities in large-scale outbreaks in the Asia-Pacific region in recent years. No vaccine or antiviral therapy is available. In this study, antiviral effect of matrine against enterovirus 71 were evaluated in vitro and in vivo. Matrine could suppress the viral RNA copy number on rhabdomyosarcoma cells. More ...[more]
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