Unknown

Dataset Information

0

Impact of halogen substituents on interactions between 2-phenyl-2,3-dihydroqulinazolin-4(1H)-one derivatives and human serum albumin.

ABSTRACT: A novel type of 2-(un)substituted phenyl-2,3-dihydroquinazolin-4(1H)-one (DQL) derivatives were designed and synthesized to study the impact of halogen substituents on interactions between DQL and human serum albumin (HSA) by comparison methodology. The interactions between DQL and HSA were studied by fluorescence spectroscopy. The intrinsic fluorescence of human serum albumin was quenched by DQL through a static quenching mechanism. Site marker competitive experiments showed that DQL bound to HSA in site II (subdomain IIIA). The binding constants, the numbers of binding sites and the thermodynamic parameters were measured too. The results indicated that the interactions were spontaneous, mainly through hydrophobic forces, and the substitution by halogen atoms in the benzene ring could increase the interactions between DQL and HSA. Furthermore, the binding affinity was enhanced gradually with the increasing of halogen atomic number.

SUBMITTER: Liu F 

PROVIDER: S-EPMC6268991 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Impact of halogen substituents on interactions between 2-phenyl-2,3-dihydroqulinazolin-4(1H)-one derivatives and human serum albumin.

Liu Feng F   Wang Yi Y   Lv Cong C   Wang Lei L   Ou Junjun J   Wang Min M   Liu Shangzhong S  

Molecules (Basel, Switzerland) 20120217 2

A novel type of 2-(un)substituted phenyl-2,3-dihydroquinazolin-4(1H)-one (DQL) derivatives were designed and synthesized to study the impact of halogen substituents on interactions between DQL and human serum albumin (HSA) by comparison methodology. The interactions between DQL and HSA were studied by fluorescence spectroscopy. The intrinsic fluorescence of human serum albumin was quenched by DQL through a static quenching mechanism. Site marker competitive experiments showed that DQL bound to H  ...[more]

Similar Datasets

Unknown 1-Allyl-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one.
| S-EPMC2979523 | biostudies-literature
Unknown 3,4-Dimethyl-1-phenyl-pyrano[2,3-c]pyrazol-6(1H)-one.
| S-EPMC3099778 | biostudies-literature
Unknown 3,6-Dimethyl-1-phenyl-1H,4H-pyrano[2,3-c]pyrazol-4-one.
| S-EPMC3344066 | biostudies-literature
Unknown 2-(Di-phenyl-methyl-idene)-2,3-di-hydro-1H-inden-1-one.
| S-EPMC3793795 | biostudies-literature
Unknown 5-Methyl-4-(5-methyl-3-oxo-2-phenyl-2,3-di­hydro-1H-pyrazol-4-yl)-2-phenyl-1H-pyrazol-3(2H)-one
| S-EPMC9462187 | biostudies-literature
Unknown 5-Chloro-3,6-dimethyl-1-phenyl-1H,4H-pyrano[2,3-c]pyrazol-4-one.
| S-EPMC3394042 | biostudies-literature
Unknown Interactions of Boron Clusters and their Derivatives with Serum Albumin.
| S-EPMC5574927 | biostudies-literature
Unknown Marine-derived magnetic nanocatalyst in sustainable ultrasound-assisted synthesis of 2,3-diphenyl-2,3-Dihydroquinazolin-4(1H)-One derivatives.
| S-EPMC11492587 | biostudies-literature
Unknown 4-((E)-{2-[N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)carboximido-yl]benzyl-idene}amino)-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one.
| S-EPMC3201528 | biostudies-literature
Unknown 2,3-Dihydro-1H-pyrrolizin-1-one.
| S-EPMC2983252 | biostudies-literature