Metallic Air Pollutants and Breast Cancer Risk in a Nationwide Cohort Study.

ABSTRACT:

Background

Toxic metals show evidence of carcinogenic and estrogenic properties. However, little is known about the relationship between airborne metals and breast cancer. We evaluated the risk of breast cancer in relation to exposure to toxic metallic substances in air, individually and combined, in a US-wide cohort.

Methods

Sister Study participants (n = 50,884), breast cancer-free women who had a sister with breast cancer were recruited, from 2003 to 2009. The 2005 Environmental Protection Agency National Air Toxic Assessment's census-tract estimates of metal concentrations in air (antimony, arsenic, cadmium, chromium, cobalt, lead, manganese, mercury, nickel, and selenium) were matched to participants' enrollment residence. We used Cox regression to estimate the associat

SUBMITTER: White AJ 

PROVIDER: S-EPMC6269205 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature