Ontology highlight
ABSTRACT:
SUBMITTER: Li MD
PROVIDER: S-EPMC6269424 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Li Min-Dian MD Vera Nicholas B NB Yang Yunfan Y Zhang Bichen B Ni Weiming W Ziso-Qejvanaj Enida E Ding Sheng S Zhang Kaisi K Yin Ruonan R Wang Simeng S Zhou Xu X Fang Ethan X EX Xu Tian T Erion Derek M DM Yang Xiaoyong X
Nature communications 20181130 1
Palatable foods (fat and sweet) induce hyperphagia, and facilitate the development of obesity. Whether and how overnutrition increases appetite through the adipose-to-brain axis is unclear. O-linked beta-D-N-acetylglucosamine (O-GlcNAc) transferase (OGT) couples nutrient cues to O-GlcNAcylation of intracellular proteins at serine/threonine residues. Chronic dysregulation of O-GlcNAc signaling contributes to metabolic diseases. Here we show that adipocyte OGT is essential for high fat diet-induce ...[more]