Ontology highlight
ABSTRACT:
SUBMITTER: Bohere J
PROVIDER: S-EPMC6269459 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Bohère Jérôme J Mancheno-Ferris Alexandra A Al Hayek Sandy S Zanet Jennifer J Valenti Philippe P Akino Kohsuke K Yamabe Yuya Y Inagaki Sachi S Chanut-Delalande Hélène H Plaza Serge S Kageyama Yuji Y Osman Dani D Polesello Cédric C Payre François F
Nature communications 20181130 1
To compensate for accumulating damages and cell death, adult homeostasis (e.g., body fluids and secretion) requires organ regeneration, operated by long-lived stem cells. How stem cells can survive throughout the animal life remains poorly understood. Here we show that the transcription factor Shavenbaby (Svb, OvoL in vertebrates) is expressed in renal/nephric stem cells (RNSCs) of Drosophila and required for their maintenance during adulthood. As recently shown in embryos, Svb function in adult ...[more]