Ontology highlight
ABSTRACT:
SUBMITTER: Liu SC
PROVIDER: S-EPMC6269507 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Liu Shu-Chen SC Hsu Tien T Chang Yu-Sun YS Chung An-Ko AK Jiang Shih Sheng SS OuYang Chun-Nan CN Yuh Chiou-Hwa CH Hsueh Chuen C Liu Ya-Ping YP Tsang Ngan-Ming NM
Nature communications 20181130 1
Metastasis remains a clinically unsolved issue in nasopharyngeal carcinoma. Here, we report that higher levels of cytoplasmic leukemia inhibitory factor (LIF) and LIF receptor are correlated with poorer metastasis/recurrence-free survival. Further, single nucleotide variations and signal peptide mutation of LIF are identified in NPC. Cytoplasmic LIF reprograms the invasive mode from collective to mesenchymal migration via acquisition of EMT and invadopodia-associated characteristics. Higher cyto ...[more]